July 19, 2019 In Masters of Beauty: Episode 05 we talk to Roland Peralta, the Co-Founder of Nutrafol. Nutrafol is the Nutraceutical wellness company that is addressing hair and body wellness. Roland talks about his own battle with rheumatoid arthritis and thyroid cancer, losing his hair in the process, and discovering natural ways to treat his symptoms and hair loss. You can now listen to this podcast on Apple Music and Spotify! SpotifyApple Music *Disclaimer* Hey everyone! Below is my most recent podcast transcript and video featuring Roland Peralta of Nutrafol! We used the best available transcription service. Please ignore some of the misspellings, and vocal pauses. We hope you enjoy this very insightful discussion about nutraceuticals and organic ingredients. Dr. Anil Shah: (00:02) Welcome everyone. I am super honored to have one of the founders of Nutrafol here, Roland Peralta. He’s an entrepreneur and he’s a biohacker before they were biohackers! And it’s interesting how his hair health, has tied with his own personal health. Just like many of us, Roland had thought there was an alternative way of doing things. So on his own, he came up with this way of treating his rheumatoid arthritis. Rather than taking some of these medications like steroids, he actually took it upon himself to use things from the plant in botanical world.Dr. Anil Shah: (00:54) Usually because our own personal insights and personal battles, we come up with these, impetus and this drive to really make something successful. And that’s what has really been the force behind Nutrafol. This company went from a startup to 30 million in sales in 2016. He’s been all over the world in the haircare industry, been with luxury brands, anti-aging brands. You’ve Been all over in this hair world and this botanical background. I was reading a little bit about your backround; your parents were, in the world of botanical health and tying this all together. It’s makes this nice synthesis of this, this beautiful product. Now you’re this driving force and you’re putting a new type of product where you’re combining the worlds of science and traditional medicine with, eastern medicine. Nutrafol, which is an amazing product; I use every day. So I know a little bit of background about Nutrafol, the ingredient process, etc. Let’s start with your story on rheumatoid arthritis, the ingredients and how you overcame some of these aspects. How long have you been symptom free?Roland Peralta: (03:00) I would say almost seven years. Some of the biologics have strange symptoms. They do have some side effects long term. They haven’t been around long enough obviously to understand the real long term implications of using them. But, when you as a biohacker dive deep under the hood and understand what these biologics do, you can essentially reverse engineer and look for a similarity in botanicals. Botanicals have been around since the beginning of time and our ancestors used plants to heal. Obviously in the last hundred or so years we have moved away from the use of botanicals, developing drugs that are very, focused. They monitor and target specific receptors; have specific genes. Botanicals have this incredible capacity to multi-target. There’s a synergy that you can find in nature and not necessarily, using, pharmaceutical drugs. So when I was looking for answers for my rheumatoid arthritis, and found certain botanicals that helped with a variety of conditions, including hair loss!Roland Peralta: (04:10) When I reverse engineered what these biologics did, it turns out that Curcumin, which is an extract, so curcumin is “hero” plant in Ayurvedic medicine. It’s been used forever in culture. They’ll sprinkle tumeric on everything. Of course, the problem with Tumeric is that it’s not bioavailable. So it’s very difficult for the body to actually ingest it. It turns out, not to get too technical, but it turns out that these biologics that were being used successfully to treat rheumatoid arthritis are TNF blockers, TNF Alpha blockers.Roland Peralta: (05:15) Well, it turns out the curcumin has the ability to block TNF Alpha. And so after two months of using this, I found a paper in the literature that that identified curcumin as a potential therapeutic for treating RA. There wasn’t enough evidence. The authors concluded it looks promising, somebody should look at it, but no, no conclusion can be made from this basically. Right? So I took it upon myself to begin to, to curcumin in lieu of using who very expensive drugs. Within four or five weeks I began seeing that I was symptom free. So having morning stiffness, throughout my body, that began to subside. Within two months I found my cure. I found my medicine in curcumin and I was using a, a particular brand that, reconstituted the powder in the oil. It made it more bioavailable. So it essentially was doing what the, folks in Indian culture are doing, where they’re cooking their curcumin and ghee butter to make it more bioavailable. So within two months I was symptom free and I thought it was too good to be true. And I continued with that program. I was taking six pills a day. These are big fat pills and obviously by any standard that’s a lot of pills to ingest, people would, you’ll end up getting pill fatigue. But the choice was an injection of biologic into my body or six pills of delicious healthy curcumin that has other wonderful side benefits to it. And so that was really the beginning of my understanding. There are answers in the literature. If you dive a little deeper, you can actually find solutions that are not necessarily being shared with you by your physician. You have to take it upon yourself to do that homework.Dr. Anil Shah: (07:21) It’s interesting that that’s actually gravitated to the NIH where ccurcumin has actually been studied I think in over 40 different trials. It’s interesting that that world, it’s really come a long way and it’s, it’s sensed a whole nother level of credibility. I think the other thing that’s interesting with botanicals is the botanicals, like is this is something you can’t just, you know, find a plant and work with it. You have to process it to a level that it’s, you know, it’s, it’s clinical grade technical set of people where you can actually look at the doses. And I think that’s the thing that a lot of people don’t realize that, hey, guess what, let me just buy this product from, I don’t know, whole foods and I have no idea what’s in it, but I’ll take it. It has it on there. So many of these products are cross contaminated with so many things. I’ll give you an example of a patient we have for surgery where she thought she was taking a weight loss supplement and it was cross contaminated with like Ginsing and all these blood thinners. She had a lot more bleeding than we thought.Roland Peralta: (08:16) So, yes. So you’re, you’re, you’re, you’re sharing with me now is essentially the definition of nutraceuticals, right. And that’s really the, the birth of, of, Nutrafol we identified, ingredients that have been used in ayurvedic medicine but have been evolved to next generation using a biotechnology to extract very specific phyto actives and then essentially standardizing it, right? So for example, we use Ashwagandha, another hero ingredient in ayurvedic medicine used for thousands of years to lower stress hormones. And so in the medical world, when we, we once did a survey with McKinsey, the big consulting firm, and one of the number one reasons why women believe they’re losing their hair, it’s stress. They believe that that’s the primary reason why they’re losing hair, not genes, not hormones, but stress in particular. So when we, when we developed Nutrafol, we saw the white space was using highly standardized nutraceuticals to target very specific pathways that were essentially being ignored by, the medical community by the pharmaceutical industry.Roland Peralta: (09:38) And we said, well, if stress is at the root of hair loss, what’s at the root of, of, stress and an elevated cortisol is at the root of stress. So we were lucky. We, we developed a relationship with a company that they conducted 12 double blinded randomized placebo controlled studies on their standardized Ashwagandha. And in one of the studies that the University of Ohio, they were able to demonstrate that within 60 days of use, because it’s not a magic pill, right? Botanicals don’t necessarily work right away, but they eventually bring your body back to homeostasis. They were able to prove that they were able to lower elevated cortisol and chronically stressed adults by as much as 35%. That’s very significant. it’s, it’s, it’s a game changer. So, and that of course when you have elevated cortisol, that becomes a, an undercurrent disrupter.Roland Peralta: (10:35) Suddenly it impacts how your thyroid hormone is being produced potentially and ultimately leading to hypothyroidism, a under diva underfunctioning thyroid. And that obviously complicates, so many things across the board. So we were as, as biohackers, we were reverse engineering. Let’s we’re, where is the problem? What’s at the root of that problem? And can we use nature? Can we use these standardized nutraceuticals to target those, those specific, markers that we were targeting. So for us was really important to have clinical evidence of efficacy and and most importantly to use clinically efficacious dosages. So what differentiated us from our competitors is that people will put a sprinkle of a DHT blocker for example, and make a claim that a saw Palmetto is used, has been used to block DHT, but the studies show that you need 640 milligrams in powder form 320 milligrams and oil. So if you have anything less than that, you’re not complying with the literature. Essentially you’re just making a marketing claim, throwing a sprinkle in and borrowing science and that, that’s really where I believe physicians have had our challenge and how realist, how viable is a natural, a ingredient, right? A, a natural product to, to address a specific condition, right? Eh, clinically efficacious dosages, abiding by studies found in the literature. Good credible studies is, is f is the first departure point in determining whether something actually works.Dr. Anil Shah: (12:15) Yeah. I always, I agree wholeheartedly with everything you said over there. I think one of the hardest things I have with patients is explaining everything that’s in Nutrafol because sometimes they’re like, well, what is Nutrafol? Because I think people like a one word answer. And when I start talking about Nutrafol I end up talking, and maybe you can do it better than I can, but I ended up talking for like five minutes or 10 minutes about all the things that are Nutrafol. And if there’s anything I have a comment it is on the back of the label. It doesn’t even like tell you everything that’s in it because I think to truly understand what’s in Nutrafol, I think some of your podcasts in the back, like when you’ve talked on bulletproof radio, it explains a lot of the detail and the thought process and how meticulously sourced your, your ingredients were the thought process behind everything.Dr. Anil Shah: (13:07) So I think somehow that, if you just look at the back of it and most patients are like, oh, it looks like a vitamin. I’m like, no, no, no. It’s way, way more than the vitamin that’s going to go in there. So let’s talk about some of these ingredients. Cause I want my patients to listen to this. I want other patients to hear this. so some of the things that I think are things that people don’t even realize, for, for example, I love the culation properties. You know, getting rid of the aluminum and mercury. and again, that’s such a hot topic. Now lots of other people are starting to copy that. I’m seeing it on the market. I’m not gonna name them. Yeah. But they’re starting to add that not necessarily per hair, but overall wellness. and so the seek help, let’s talk about the seek help.Roland Peralta: (13:47) That’s a great question. I’m impressed that you actually even know, about seek help and the role it plays. So, to answer your, your overall questions, people say what is Nutrafol? And so we say that we, we are the first to market to use standardized nutraceuticals derived from botanical. So we isolate very specific phytochemical from botanicals in specific concentrations that have evidence of efficacy and targeting markers. And so what are those markers? So we target, the ingredients, target inflammation. And people underestimate, how inflammation, triggers or causes hair loss or contributes to it. So we, we understand that we live in an environment where we’re constantly producing inflammatory conditions and, and it, some of us micro inflammation in some macro, right, leading to obesity, diabetes, etc. Micro inflammation is just a walking time bomb.Roland Peralta: (14:55) If you have a genetic predisposition then that, that those events are essentially the trigger that it pulls the gun, right? So, so the, we say inflammation changes the, all the signaling molecules that control the hair growth cycle. So in the presence of inflammation, those signals that actually signal hereof cycles to remain an antigen are altered. There’s a disruption in the signaling. Same way a cell phone is trying to communicate with a cell tower, it’s a weak signal. You’re not going to be able to communicate. You have to lower inflammation to essentially improve signaling. The second marker that we target is the elevated cortisol. How do we lower stress hormones? Cortisol. And again, some of us may think we’re not stressed out, but in fact, we even use the term micro stress levels, right? Where you’re just like that cute, that cumulative effect of the inappropriate response, the inappropriate fight or flight response to a bus honking his horn or some guy yelling at another guy in a car across the street. And that,Dr. Anil Shah: (16:03) yeah, who’s not stressed out. Exactly.Roland Peralta: (16:04) Do you get stressed out? So you produce that, that micro response to that stress response and that cumulate that just accumulates over time. So again, once again, it’s just a matter of time before you are stressed.Dr. Anil Shah: (16:19) And, and I love explaining that to my patients. How, you know, when your body’s stressed, it puts all this nutrients in it. it’s going to put it towards heart and your lungs. And the first thing, it doesn’t care aboutRoland Peralta: (16:30) his hair. There we go. Here’s the first thing. So hair is the hair follicles are mini, Oregon’s, right? And that is mother nature says heart liver, the priority deprioritize the hair follicle, Oregon because it’s not involved in, in, in survival the survival mechanism. Right? So, and, and people don’t understand that. They don’t quite connect those dots. So the other marker that we target is DHT. DHT is a, is a byproduct of testosterone production as you know, it can, when testosterone converse to DHT, it’s a simple little enzyme that allows that conversion. DHT contributes to the miniaturization of hair follicles. When people talk about it more prevalent in men, that that is ultimately what triggers, the top typical hair loss and men, Andrew, Daniella, p HSA. But in fact, as women get older, over 40, 45, they start producing higher levels of testosterone, which converts to DHT. So we’re using a natural ingredient. And as you know, Propecia has a similar mechanism of action. It targets the enzyme that converts the, allows the conversion of testosterone to DHT. So we use a natural plant indigenous to a, the state of Florida that is harvested a year. And we, we use a cold press technology to extract it so that it’s standardized to greater than 45% fatty acids and effective DHT blocker. Dozens of studies in the literature that show the efficacy of, of Salt Palmetto as an effective DHT blocker.Dr. Anil Shah: (18:09) Love it. And I think there’s a couple of studies that you’ve put in the past. I mean the, the, the, one of the questions patients ask is if we’re talking about software matter right now, saw Palmetto, versus Propecia, I think of it as Propecia. I mean, do they work? They both work. Propecia, the problem is with Propecia is it’s going to inhibit your sex drive in some cultures. Saw Palmetto is actually used as an aphrodisiac, right? Good. Could be a choice. So, and guess I’m a former, I’ll raise my hand. I’m a former pro Kesha user. So, and that aspect of it I could talk to about my experience about in a little bit, but we’ll, we’ll dive into the saw palmetto. It’s interesting when they isolate saw palmetto and some of the active ingredients in it, and not to dive too much into basic science, they’ve actually found in some studies that it’s actually stronger than Propecia in some mouse models. So it’s interesting that, you know, where it works, how it works. It’s, I don’t think it’s, it’s effectiveness and hairs questioned and it’s just getting that delivery product. So it’s an invaluable product, valuable ingredient, having it processed the right way. Again, it’s all in that, in the nutrafol aspect of it. so I’m a big fan of saw palmetto and, the studies support it, but more than me being a big fan of it, steady support it being effective.Roland Peralta: (19:21) that’s great. I’m, I’m happy to hear that you are supportive. We actually have, we found papers in the literature that show because it’s unnatural, there’s a there and there are synergistic properties that saw Palmetto can actually bind to the, to the five Alpha receptor, preventing DHT from binding to the receptor. Propecia doesn’t do that. It only blocks the enzyme. So if there’s, if there’s a byproduct or or, or free DHT, you have the potential, it has the potential to have additional preventative, properties in blocking that binding, which is interesting.Dr. Anil Shah: (20:00) If I talk about my Propecia use in the past. So I’ve, you know, hair’s been always been an important part of me and I’ve, I’ve had some hair recession, I’ve had a heart transplant, I do her transplant to my office and I did it with artists. but, it’s, that aspect of it. I use Propecia and I don’t know, I felt like Propecia was like causing all this hair growth. And when I did it, I tried it first. I stopped it cause I thought maybe I was having some symptoms, not physical, but it’s sort of part of like, you know, my having less energy, I did it and said, screw it, I’m just gonna take it. And you know, whatever happens, happens. And, I stopped. I know what I did is I weaned myself with Propecia, believe it or not, with neutral fall.Dr. Anil Shah: (20:37) So what I did is I started taking one or two tablets of Nutrafol with Propecia, and then I would start to miss a day of Propecia and keep adding more Nutrafol to it. And then what I would do is you sort of, again, I have the advantage of having try cross scopy. So I was looking at my head. That’s great. I would look at my minis, I would kind of, I think shouting for me is really hard to quantify because it’s sort of like tough to tell, you know, some people can really have a good sense of that, but shutting the normal process up here. So we’re looking at my mini minis, quantifying my heritage. I was going along. And then what I noticed was, when I switched completely to neutral fall, which has been a, I think it’s going on 10 months, 11 months.Dr. Anil Shah: (21:17) I did not have, like, I was worried about all this hair shedding. Nothing happened. My hair, xxx if anything, my hair. I do a lot of stuff though, but my hair, if anything is fuller. and it looks, I mean it’s pretty full. I mean it’s pretty hard to see some teeth do. and you could see pictures of me on all over the place. but what I noticed when I was taking Propecia was, it’s sort of like when you, when I stopped, I felt so much, like there was like this little break on I my energy, like this little break that I didn’t notice this little break on my mood. and when I stopped, I felt so much better. Like this little weight was lifted and, so, and I’m pretty active all over the place, butRoland Peralta: (21:55) I’m super happy to hear that there was, there was a, there was a terrible incident in France where they attributed a suicide to a young man who was using Propecia and he believed that it led to him having suicidal tendencies leading to depression. So it’s not surprising these, all of these anti, finasteride organizations that exist today are, are really, bringing forth the research and all of these anecdotal papers on the downside of using finasteride. Right.Dr. Anil Shah: (22:26) And it, for so much of my patients asked me about croquet shot if they’re pre having kids, because Propecia is only an option for our users. It’s only an option for men. Women can’t even use it. So if they’re pre having kids, it’s not like I don’t say don’t do it. It’s because the option with this is who knows what’s going to happen. We’re finding right now that older men, maternal men who are over like over the age of 50 and 60 and 70, their sperm quality. It’s getting affected by the environment in, by drugs being by alcohol. So Propecia affects your hormones. So what’s that going to do to your, to your offspring. So that’s enough better. So I started after kids. I don’t want my patients taking it pre-kids because who knows what’s going to happen, what are the longterm effects? I agree.Dr. Anil Shah: (23:09) I agree. If you’re going to take it definitely after kids did. I think the sweet spot, again, if you’re going to take it, it’s only men without physical side effects who are going to have some prostate issues, who are going to be, I put it plus 50 because that’s the, that’s the aspect of it. But they have to, again, me personally, I don’t like taking medications. It’s not something for me. But if my med patients want to take it, they’ve taken the path, I’m okay with it, but it’s not something I do personally. So that’s, that’s I interesting.Roland Peralta: (23:38) No, and I appreciate that, that perspective. So we have a, there’s a study done on the Ashwagandha that we have. We use a Nutrafol, when ours is standardized to 10% with analytes. So that one of the most potent parts of that plant are the with analyte group. And so we have, our, ours is standardized and present. So there was a study they where they, they tested men in andropause and they showed using, Ashwagandha standardized number seven with that, with analytes over 90 days improved the sperm quality, the motility and the quality significantly. So the conclusion was older men who are planning on having kids who want to improve sperm quality should be taking Ashwagandha. And of course we understand the mechanism of action is likely elevated cortisol leads to compromising all systems in the human body. so yes. So for whatever it’s worth, Ashwagandha could be the antidote to having compromised sperm quality after this purpose or use. You can do it. You can do a clinical study on that. I love it. Actually,Dr. Anil Shah: (24:46) here’s the thing about, I forgot. So, so I’m, I’m the only Nutrafol user in my house. I have kids, three kids, and my wife has, she has her own hair story and and so, but that she couldn’t join us tonight. kids, sorry. but, it’s interesting then when everyone’s sick in the household, I don’t get sick and I’m attributed to the Oxford GondaRoland Peralta: (25:10) and the curcumin. So, so you bring up a really good point. So, when we first started, marketing nutraphyl as a side note, we would say, think of it as a powerful anti aging supplement because, there are ingredients and going back to the sea kelp, which we never answered that question, but, one of your primary, goals in eating a, greens and fruit and maintaining a healthy diet is to actually improve antioxidant production, right? And so antioxidants like gluten [inaudible], that’s the mother of all antioxidants. These are, these are, antioxidants that improve the immune system, right? So, so the core cumin improves your immune system because it leads to glutathione. Increased production of Glutathione, catalysts, enzymes, a s Odis, Osh for Gonda improves [inaudible] production seek help, improves glutathione production. And you need glutathione to x two key late metals like mercury, aluminum from the liver.Roland Peralta: (26:16) So anything that increases glutathione production leads to more optimize liver conditions, right? And so liver plays a critical role in hair growth and people don’t understand how important delivery is. So we as a company have introduced this systems wide approach. We can no longer look at the hair follicle as an isolated Oregon, but rather what’s the relationship of the liver to the hair follicle? What’s the relationship of the adrenals to the hair follicle? T what’s the relationship of the gut to the hair follicle, to thyroid, to the hair follicles? So we, we have, we now understand that thyroid hormone is actually converted in the liver. So if you have a sub optimal liver, because you have mercury, you have, a led, your, your hair will suffer. One of the ways that, that, that, that works is that selenium is critical for converting the t four hormone into the beauty hormone.Roland Peralta: (27:18) T3. If you have metals in your body, selenium is necessary to bind to two mercury. So Tequila, mercury from the liver, you have to have a good abundance of selenium. The problem is, is that it’s, it’s been depleted in our soils for our food supply is now deficient of many micro nutrients, critical for lots of, functional cellular function, including hair. So the body says, I have to choose between removing the mercury from the liver or contributing to the conversion of t four to t three to promote the beauty hormone. Clearly we a it survival of the fittest. The body chooses to focus on kelating the mercury. Of course, mercury is now a problem because it’s, it’s so, it’s heavily, found in our oceans. big fish like tuna and shark cumulate mercury Veggie gets into our bodies. if you have amalgams from procedures, as a child and this, it’s that avoidable. So yeah. So, so it’s important to, to have ingredients that help boost the immune system, help Tequila aid, help contribute to healthy thyroid function.Dr. Anil Shah: (28:29) And I think the aluminum component is probably underestimated as well because there’s only one exactly Yoder heads. And I think there’s only one ingredient that actually is an antiperspirant. And that’s aluminum. there’s nothing else that worked. I noticed when people talk about natural deodorants, I don’t know if they work. So the problem is twofold. You can either do something. I’m a facial plastic surgeon, so I did a radio frequency to my underarm area, so I don’t tweet as much, but occasionally I still wear antiperspirant because if I sweat a little too much, I mean I got rid of most of my sweat, but I struggled with a little bit. but your only alternative is either to do something with radio frequency or mirror dry or sweat, which most people don’t want to do, or aluminum and yeah, so,Roland Peralta: (29:12) so, so yeah. So, so I use a, I use, I used to use, slices of fresh lemon, which is a antibacterial antimicrobial. And I would rub the lemon under my armpits and that would be good for three days. So I wouldn’t have any musty smell for three days. But of course, if you ran out of lemons, you would leave home and head to the office. And by the end of the day, you’re a a little musty, right? Dr Kogan, who’s, who’s here at, introduced me to the east ty salt crystals. These are these sticks that you buy. I buy it on Amazon, six bucks, natural salt crystals in a, in a a tubular shape. You put it on a little water and it kills the odor. So it works as a, an anti deodorant, but not an antiperspirant. You still smell it, you still sweat, but you sweat with no smell. So that’s the trade offDr. Anil Shah: (30:06) he has. If I wear like a tee shirt or something like that, I just don’t like having to say no. So I’m, and the next thing that happens is then I have, you have a choice of either having to stains, if you were the antiperspirant, you have the green mark that never no dry cleaner in the world can get out. And so I’m like, okay, I’m just going to probably that part. But aluminum is an inevitable part. Mercury’s inevitable part. So if you don’t key late it again, everyone who says they’re not heavy metal, they think about that. There’s always an Aha moment. Like, oh a gosh, I do that, I do that. Yeah. I probably have that, my body. And what are you doing to get rid of it?Roland Peralta: (30:36) That’s exactly right. So we, we did a very interesting experiment. We, in the last two plus years, we’ve conducted over 3000 case studies using hair samples that we send to a lab. The lab uses a inter coupling plasma spectrometry, a mass spec device that can analyze forensic laboratories, use these devices so they can analyze the hair and we can see, levels what level of mercury is in your body based on how that mercury is being excreted from the body. So the hair essentially absorbs it. So hairs, I got as a measure of time, like a tree trunk, right? We see aluminum. So of the 3000 case studies that we did, we had a little over 65% of our cases all had toxic level levels of mercury. So outside the normal range of acceptable, right? And so all of those people where we recommended that they start using botanicals to help key late these metals from, from their body. so we actually came out with a liver liver cleanse recently as part of our, systems wide approach where we’re using milk fizzle and other wonderful botanicals that actually are known to bind to metals and help collate them from the body. Very, very important part of being proactive and maintaining a preventative approach to, to healthy hair growth like grain.Dr. Anil Shah: (32:03) Beautiful, beautiful. It’s really exciting. Yeah. and so some of the products that we talked about cc calc already I think a little bit. Yeah. Gone Duh Duh. I go, we talked about curcumin. we talked about there is buy a tin in there. Correct? There is. Right. And it’s funny because I split out, my, I brought going to go up a little bit because there was a podcast and there was a paper that talk about by tin. I did one issue. The only patients we have that don’t take Nutrafol aside from patients who are under 18 pregnant of that aspect. Our patients who’ve had, and I don’t think it’s a real allergy, so we have who said, you know what, I’ve tried by 10 in the past and I have this really weird reaction and then they’ll make a breakout, we’ll need some flushing. And some, it just didn’t work well with them. And so unfortunately at that point they were like, well I don’t, I don’t want to take it because it has biotene in it. And my thought is they’ve either taken high dose of it, they’ve gone too high in that or it’s been cross contaminated with something else. but that being said, the by 10 element, it’s quote unquote known for hair and nails. But that being said, your thoughts on the biotin element, that’s the one,Roland Peralta: (33:17) it’s such a great question. So when we did this McKinsey survey, w w the majority of the consumers believed that biotin was in the top three, products that would help save their hair and contribute to hair growth and stop hair loss. Right. Last year, Dr Jerry Shapiro, do you know Dr Shapiro at NYU?Dr. Anil Shah: (33:43) I was at NYU way back and yeah, I don’t really know him that well.Roland Peralta: (33:47) He’s Canadian, a hair loss researcher. He’s published over 150 articles. Oh Wow. All related to here. Biology. And he and his team did a Meta analysis in the literature on Biotin and the conclusion this was published in the Journal of Drugs and dermatology. The conclusion they came to was that by a 10, a is nothing less than a media infatuation that spun out of control, and it made its way into medicine. So today I understand that residents and medical school are still being told to prescribe 5,000 micrograms of Biotin to women with hair loss because it’s not going to hurt them. And because we don’t have much else that we can give them, hopefully that’s changed in the last couple of years. But what we do know is that Biotin is, is a very, very small, component, for a solution. In other words, you can develop a product without Biotin, that would work.Roland Peralta: (34:47) but the consumer believes that it works. It contributes to the citizens of certain proteins to help process Collagen. Right? But nobody has a biotin deficiency. It worked in a mouse study that had a defective gene that wasn’t producing biotin. So as soon as they replaced it, hair grew back and they said, oh, that must be a, what’s triggery hair loss? That was in the 50s. I think so by, if it is a myth. And we as a company, we’re trying to debunk that myth and say it biotin alone will do nothing for you. It’s important that you have a comprehensive formulation that targets the cortisol hormone, the inflammation, the oxidative stress, boost the immune system, the those end and the end the micronutrients.Dr. Anil Shah: (35:32) Yeah. And I think that I, I agree with you and I don’t think in 99.9, nine, nine, 9% of people by can is not harmful. And past aspect of it is, it’s, it’s not conclusive what it does and its aspect, the other ingredients that are surrounding it, or any, anything gonna amplify, what potential effect it could have.Roland Peralta: (35:51) Correct. And so, so to conclude, we often say that, and it’s not really funny, but, biotin is the prescription for endless hope. And if, you know, if you know it’s not gonna do anything. And the reason why you’re being told by your elders at teaching hospitals to give it to a patient, the argument is, well, it’s not going to hurt them. But the reality is that I think you’re hurting a woman when you’re giving her false hope and let, letting her think that six to 12 months of using biotin is going to lead to a stop the hair growth. So it’s a placebo, right? AndDr. Anil Shah: (36:27) in men it’s Co, not men, but women patients who are older than 40, it can be a little dangerous because you can mask, you know, traponin levels in an MRI. So I, some things we give, I think those are higher doses of by attends. I think smaller doses, it’s really not going to do that. but you know, smoke. But that aspect of it bites it alone. Yeah. I think with other things in a smaller dose, I’m, I think it makes sense.Roland Peralta: (36:50) So I want to slide, I want to get a petition going and, and have the 10,000 dermatologist right by 10 off, from the standard and guidelines because it’s still being recommended in, in residency, which is fascinating if you think about it. I mean, you, you agree as a position, it’s absurd to, to, to, to prescribe something that has no evidence of efficacy.Dr. Anil Shah: (37:10) Yeah, I’ve never been a biotin fan, but I think the problem is it sucks. It’s so ubiquitous. Like if you go to a, I think, you know, it’s hard not to see it. If you go to the hair and beauty section and you look down the hall and I want to grow something for my hair, it’s like a thousand labels of Biotin. Yeah. And there’s nothing else. And I think what happens is sometimes people just look for an option and they don’t know. And it’s so easy, like, well, buy a tin, it must work. Why are there some things on it? That’s right. That’s right. So it’s like a default, the placebo like,Roland Peralta: (37:37) but if you have to bet placebo, that’s the best way to describe it. Right.Dr. Anil Shah: (37:41) okay. So I’m going on to some other ingredients. The marine extract. So this is actually interesting that the foresight in Nutrafol, because there’s been some calls, I’m not going to name it, another brand that uses marine extract. And there’s been some controversy using shark, in that. And Nutrafol does not use shark. I’m gonna repeat that. So people are, have that clear. Yeah. And having the foresight to look, you know, beyond just what’s healthy for us, but what’s healthy for our, our world and our planet. and so let’s talk about how that, that came to be and why it’s where it sourced. Cause I think that’s an important quality.Roland Peralta: (38:14) I appreciate that. You know, that actually, that that is, it’s such an important part of our ethos, sustainability and where we continue as a business to be involved in, in that, in that area. How can we minimize the, our footprint on the planet and contribute to overall planetary wellness? Right. we tested our product using the mass spec device against that other product with the shark, component. And we had zero mercury in our, in our, in our collagen versus their product. And part of the reason, of course, because shark is a big fish, it’s going to accumulate, mercury. We’re using cod source from the northern most tip of the planet. So it’s nor it’s north of the northern most tip of Norway. So that, that, that part of the world, it’s, it’s, it’s almost free of, there aren’t any shipping lanes and you made your shipping lanes that go through there. So there’s a lot less pollution that’s dropping into the ocean. So, the good news is that we’re, we’re very proud of the fact that, we found no mercury in our, in our, our fish college and we don’t talk about it in our marketing. but, but we know we can actually sleep at night knowing that we are not, contributing to the, we’re not using, you’re creating a product that’s contributing further to the problem. That’s ultimately creating the problem. Right.Dr. Anil Shah: (39:43) So this is the conversation I have with patients. So now I’m like talking to the patient, I’m pocket about neutral. I’m already, until I get to your products, I’m like, Oh wow, it’s already 10 minutes in. But I’m excited about the product because it has so many things built into it. Did I miss anything, any ingredients? I think there’s some things I missed. What I think.Roland Peralta: (39:57) Yeah. So, so we’re using a Tooker Trenell, which is a super vitamin E, and that was a molecule discovered only in the last maybe 10 years. And, our partner, is extracting it. Basically, vitamin E is a trend, aisles are 60 times more powerful as an antioxidant. And there was a study done on this, particularly ingredient alone. They showed after eight months of use just lowering lipid peroxidation, they were able to show significant hair growth in a, in a study with men, which is very interesting. And Lipid peroxidation is just a byproduct of life, right? It’s, oxidative stress, so that triggers inflammation, et cetera. So boosting your antioxidants, essentially the Tucker Trenell is an antioxidant, correct? Because it has the ability to boost the, the, the antioxidants in the immune system. So that is a great ingredient with evidence of hair growth, as an individual ingredient. we talked about the seek help. One of the other important, paths and targets that we look at is, and estrogen dominance, right? So seek help core cumin all have anti estrogenic properties, they can contribute to lowering, elevated estrogen levels caused by Xeno estrogens, consumption of bottled water, as soy products. But that sunscreens, sunscreens, a huge topic because ofDr. Anil Shah: (41:34) the absorption of if somebody thinks in causing, the other says, you know, I’m estrogen effects super big.Roland Peralta: (41:38) It’s, it’s big. So those are, those are important. We developed our, so again too, as part of our systems wide approach, we created 12 additional boosters that we designed to increase or boost the efficacy of our core formula. Right. So we have the core women’s product, clinically studied, proven to work on its own. We have the men study, we’re doing a clinical study in Chicago, as we speak. We should be wrapping up enrollment any day now. And then we just introduced a product called women’s balance, which is for women in menopause, pre, peri and postmenopause. So is that the similar to the core plus or that that’s basically it. Yeah, so we just changed the name from core plus two to women’s ballads. And that’s designed because women, women over the age of 45, their hormone levels change are very different from women in their twenties and thirties.Roland Peralta: (42:36) And so what are the primary, reasons why we introduced these additional boosters was because we, we essentially understand that personalization or precision medicine is the wave of the future. If we can personalize an experience for someone, we have a better shot of succeeding for that unique individual. So our B complex was designed specifically with it, with dosages of two particular ingredients that are known to be anti estrogenic at the levels that they were introduced. So we’re essentially helping the liver clear estrogens from the liver, to prevent estrogen dominance because we know that elevated estrogen can be a braking mechanism on the hair growth cycle. There’s a great paper on estrogen and hair follicle biology and it, there was a fantastic section on how elevated estrogen levels could lead to a shorter antigen phases, which is the growth cycle.Dr. Anil Shah: (43:39) And it’s interesting, my wife has more background in homework than I do, but you’re talking to patients who actually do testosterone supplements and things of that nature. oftentimes patients are worried about their hair loss, but it’s usually not the fact that as testosterone, it’s usually an imbalance with the estrogen, testosterone correct aspect. And Estrogen is the been an understated bad player that people have sort of like wrapped it all into DHT. But estrogen’s pine playing a stronger role in most people are realizing.Roland Peralta: (44:06) Exactly right. So, and that’s probably because, and you think about women in the last 30 years suddenly have hair problems. My mom growing up in South America said it was, it was rare that you saw a women losing her hair. Today, everywhere you look, there are women with thinning scalps. Right. And we believe that stress levels play an important part of that because in the 21st century, I’ve had to step up. 20th Century, 21st century women have had to step up to become a breadwinner’s. So providers, single moms, a lot of pressure to, to, to basically support themselves. Right. And in many cases, and also the, the Xeno estrogens from environmental triggers, right. Also contributing to, to, to hair loss, globally. So part of your strategy is how do you lower that? How do you optimize the liver so that the liver, which is the filter for the human body, can expel those used estrogen hormones. One of our key ingredients in our women’s menopause formula is Maka. It’s an organized, skeletonized Maka, which is another hero ingredient used in traditional medicine. And it’s used as a hormone sensitizer. It’s essentially the conductor for hormone production. If you’re producing too much testosterone, it helps recalibrate the body and say, Hey, wait a minute. Too much testosterone, but not enough progesterone. Let’s change that ratio, which is why Makkah is used as a to improve stamina and energy.Dr. Anil Shah: (45:45) And my brother, who’s an ob Gyn, actually, he loves Mako first, especially postmenopausal patients. So he’s a big fan of Maka and he, yeah,Roland Peralta: (45:53) I’m so happy to hear that, that your whole family is so conscious of, of, of the power of plants.Speaker 3: (45:59) I wouldn’t, I wouldn’t get my brother too much credit. He drives a pickup truck and he’s just parties. Yeah. What he balances out with the Maka. He has imbalanced with his pickup truck in his, of his, love of guns, balancing it out. As long as he’s not telling every woman that comes through his office to buy a gun, I, I still support him. He’s not, I’m happyRoland Peralta: (46:27) here that he’s, he’s, he’s, he’s, he advocates for the use of mock guy. And Maka has a fantastic herbDr. Anil Shah: (46:32) for me. What I do, and my wife does most of the, the management with women with hair loss. But one of the things that we’ve talked about and I’m dealing with is when we look with Tricon scopy, we’ll see distinct patterns of hair loss. And I think in men it’s usually a little bit more predictable, but not always, but in women, they can be all over the place and we’ll see some women who are, you know, with, with cluster, with male pattern who are in their twenties and thirties and some patients who are, have more inflammatory, who are older. So the way I’ve, we’ve talked about using Nutrafol is women and, and my understanding is that Nutrafol plus has more salt, Palmetto offer swimming. And so, I view it as almost that little extra way of fighting that, androgenic alopecia and women. So if I see miniaturization, classic male pattern baldness, the tricon scopy I’m going to go with the women’s plus, even if it’s a younger patient. And if I have an older patient who has inflammatory changes and a trichotomy, I’m seeing more, some more red, more vascularity. I might just go with women rather than women plus, even though they probably could benefit from that, I still might go that way cause I don’t see the miniaturization. Is that against company? No. OneRoland Peralta: (47:41) a hundred percent no. I, and I see it, it’s physicians like you that have the foresight to step out of the box and see, the big picture and understand the benefits of deviating from directions. And as a doctor, you’re, you are authorized to do that. There’s no harm. There’s only benefit in using a higher dose for that particular, observation. I would agree with you.Dr. Anil Shah: (48:06) Another question on this is, some people don’t like swallowing pills, so is there any, so any nutritional value in the capsule itself? Some people think that there’s Collagen in the capsule or they’re gonna miss out on it. They’re like, I need to get my college so I have to do this. Or can you just jump into their smoothie? What’s, what does that,Roland Peralta: (48:25) no, so there’s no nutritional value in the capsule. We do use a vegetarian capsules as opposed to capitols made from bovine, by animal byproducts. but there’s, there’s probably negligible, nutritional value in, in the capsules. So, yeah. So if you have difficulty swallowing pills, you can either watch a video on youtube on how to, how to lift up your head and learn how to swallow a pill properly. Or you can break your capsules open and put it in a smoothie. there’s a little bit of a bitter taste. The seek help, it’s just seek help. A little bitter, a little salty, right. But, saw Palmetto is, is a little bitter. Ashwagandha is actually bitter, so I’ll put less bitter. But, you should be able to cover up the taste. If you’re having a fruit smoothie, we recommend putting a coconut oil or some other fat, maybe an avocado in your smoothie because the more fat, the better you are able to absorb many of the ingredients. A lot of the ingredients are fat soluble, so you need fat to help absorb that.Dr. Anil Shah: (49:30) And speaking of absorption. So I, recently I’ve tried the probiotic, and I am a big fan of it. I, I was not a probiotic fan before and I’m not, I’ve been off dairy for a little bit so it’s not working well with me, but probiotic, this is actually a pretty clever probiotic cause the way I describe it as, sometimes you have like this uneasiness in your stomach where it feels like it’s not like you’re stressed or anything. You just feel like this little bit of uneasiness in your stomach. When I’ve taken the probiotic, I noticed that I’ve slept a little better and that I, that little bit of, upset and my stomach has seemed to balance out a little bit.Roland Peralta: (50:06) Interesting. So, and if you continue to use it, you’re going to see that it’s only going to improve. So, one of the biggest areas of research in microbiome right now. So we, we developed a thank you for introducing the, the hair biotics. So we developed, we’re the first to market to develop a probiotic designed to support the hair cycle. So, we, there are a number of pathways that were identified that downregulate the hair growth cycle, because they, they affect aisle 17 and on aisle 10. Two important cytokines that are involved in the inflammation cycle. Those centuries tied back to hair growth, right? So those particular cytokines can be impacted by particular bacterial strains. So we isolated a, we found two out of the seven strains that we’re using have that, have been shown in literature to target those specific pathways.Roland Peralta: (51:02) We added in addition to those strains, we’ve added a, what’s known as it bacterio fudge and bacteria. Faraj is essentially it’s a virus. It’s a, it’s a, a researched, this is part of the whole volume that people are investing heavily. Now. We’re, we’re, we’ve been heavily invested in the microbiome. Now it’s the volume, how to viruses play a role in contributing to healthy gut. And so these bacteria with fosters are designed to essentially, eat, destroy bad bacteria. So it’s possible that the bacteria fosters and the probiotics and contributing to a healthier gut so you’ll feel less bloated, less, less. yeah, less, discomfort in, in the gut. So it doesn’t surprise me that that’s going to happen over time. If you continue using the Nutrafol hair biotic, you, you may see a dramatic improvement within a couple of months and that of course contributes to better hair growth.Dr. Anil Shah: (52:01) Absolutely. and I think what’s interesting is it neutral Paul, I think it’s added this addition, like you mentioned this earlier, this like this customized her plan, which I think is an exciting addition. and, and now there’s, there’s, there’s the, the core formula which, which helps, you know, most people I say most people mean a sense that women, men and, and the, the acceptance are going to be maybe those people with biotin sensitivities and pregnant women in that aspect. And now you’re adding these little, I say a little bit these boosters that can fine tune it so you can get improvement in certain areas. I’m also interested in the topicals. I’m not sure if you can talk about the topicals and shampoos coming up cause I’m really interested in that because right now I use, I’ll talk about it now cause I’m excited about it.Dr. Anil Shah: (52:45) right now I use Rogaine. but I don’t love using Rogaine and I’ll tell you why. it’s not, some people have other issues with scalp irritations, all those aspects of it. Even the ones without propylene quite call the foams. What they do to your hair is it makes it very greasy and it’s very hard to style your hair with it. I don’t use down the hair products because I’m against inflammation in the hair and I just don’t like the aspect of it just makes sense to me. But you know, from a hair preservation standpoint to put you know, products in your hair, they at least they’re going to disturb it. So, there’s really no alternative to Rogaine as far as the topical goes. There’s some other things that I, I don’t know if they they’re out yet, but, so I’m excited about Nutrafol and your take on that. Is there anything you can tell us about the hair topical coming out? Cause that’s probably when I saw that I was like, my eyes lit up with excitement.Roland Peralta: (53:35) So yeah. So we, we are introducing a shampoo, conditioner and a two in one. And those were, those were developed with, with the, with the intention of creating a product that does no harm. So there’s no, there’s no evidence of shampoo and conditioners having any efficacy in preventing hair loss. Even though if you go on Amazon, you’ll see dozens of brands promoting shampoo for hair loss, right. Impossible. That you can put a product on your hair, wash it away two months later, expect it to have any efficacy, if maybe contributes to healthier scalp, which ultimately one day may lead to minimizing hair loss. Right? so we, we refer to those topicals as are do no harm products. We’re using lots of wonderful botanicals that have antiinflammatory properties, moisturizing properties, but, but all, all in all, there’s no such thing as, as hair loss, in the haircare category, the, the scalp treatment that we’re using, we’re using, again, nutraceutical ingredients that have, anti, and these are leave ons.Roland Peralta: (54:42) So these are, these are Levens that have evidence of stimulating the antigen phase or prolonging the antigen phase. some of the ingredients, act as Vasos dilators where they, they’ll open up the capillaries, similar mechanism to a Minoxidil, right. But obviously not as potent because these are naturals. So the, the scalp treatment that we developed, there is evidence that the ingredients contributed to hair growth. so really we’re adding it as a, an additional product to compliment your routine. Right. We would, we would say don’t drop the, the, the, the, the pills, the four pills a day over the topical because that’s our philosophy. Still hair wellness from within. You have to balance the body, bring the body back to homeostasis before you can actually get the pear cycles back in sync and start producing healthier hair at normal growth rates. Right? So the, the, the topicals are designed to simply compliment, the overall internal, systems wide approach that we have. It’s just the inside, outside approach really. I’ll make sure we send you some when we get it. Awesome.Dr. Anil Shah: (55:56) And I think this is such a new category, the nutraceutical, and I think it’s, something that so many people are so excited about. And it’s interesting that lots of physicians, even though they prescribe medication, oftentimes when you talk to them, they don’t see the doctor and they don’t take medications. So it tells you on some level that maybe on some subconscious level they know that they don’t want to take medications. And for myself, for example, I was found to have at least in one test, low thyroid. And I was like, I’m not picking a thyroid quote. I’ll be picking up for the rest of my life, so let me just check it out. And so, I again, I’m just saying I’ll just avoid taking that medication. I’ll work on some other things and that aspect of it, but the average normal, otherwise I’d be on Synthroid. Cause once you take a medication like that, it does work, but you’re ended up relegated to taking that the rest of your life. And there are patients, I’m not against medicine, they’re patients you have to take medications. But if you’re talking about wellness and keeping the best performance for yourself, if you can avoid taking a medication for that aspect, it makes a lot of sense to me.Roland Peralta: (56:58) The grief now are, is your thyroid functioning normally now? it is, my wife would probably rather have me onpro [inaudible] less sex drive. I’m more sluggish. Huh? Leaving her alone. But that’s hysterical. So, so on that though, you’ll appreciate this. So many of the ingredients, the botanicals that we use are boost nitric oxide production and did you know, so that’s a, that’s actually a thing. So, but there, there basically is a vasodilator. Right. And did you know that Viagra doesn’t work if you have low nitric oxide production and definitely no. The viagara nitric oxide connection. I didn’t, I didn’t have that with Nutrafol, but so I might change the symbol from a circle to something maybe perhaps a little bit more, Balak and then I’ll let you send it in for creative to have a look at. But earlier you said that, so, yeah. So in, in traditional medicine saw Palmetto was used as an aphrodisiac, boost libido, right? And saw Palmetto, definitely booths, nitric oxide production. So when you think of it from a mechanism of action, that has to be the explanation, right? Or that, that the Ashwagandha, the curcumin all act as Vaser dilators through the increase of, of nitric oxide production, which is a very interesting little fact.Dr. Anil Shah: (58:24) And, and so care health ethics. Some patients come into the office and it’s always about, for example, if it’s a surgical procedure or if it’s a pill. I always like to set expectations for patients. And so sometimes you’ll hear someone saying, you know, I tried something and I tried it for like three days, nine the same thing. I’m like, oh my God, okay, this is the reset things a little bit. And I think that’s why I think having that explanation and having, making sure people know, and I’m glad it’s being sold in packs of three now instead of one, because oftentimes with anything with any nutritional supplement, you’re not going to see something in a week. It’s going to be one of those aspects of it. And it’s beyond just hair health. So I think when I think a pair, I think of it almost like there’s two analogies.Dr. Anil Shah: (59:06) One is like, aging. There’s no solution to aging. It’s just you’re putting the brakes on everything. And no matter what you do for hair, if you do nothing for your hair, you will be bald. It’s like, it’s one of those things if 50% of the minute a 50 are ball, if you do 70, 70% of men, your natural tendency is to be bald. And it’s it just without a doubt. So you have to put the brakes on this and as much as you can, as early as you can, and you have to promote care, health and as aspects, some men are going to get reversible, a lot of the miniature hairs are going to come back. But if you waited too long, if you have a Norwich per patient, you don’t never know what six is. Basically, if you’re completely ball, you, no one in the world can grow hair back.Dr. Anil Shah: (59:49) That’s it’s scar your hair. You have to kind of, that’s right. You’re, you’re actually beyond even a hair transplant at some point, right? So, you have to start this early. So for the men who are thinking of this, this is the preventive action, you’re going to feel better. so, patient expectations setting this back is you should feel better. This is what my thoughts on this. You should be healthier, which I think all good things happen with it. And you should see your hair. It should actually at the very least have less chatty. And you might see some areas particularly I think in the crown starting to come back. So all the miniature hairs coming back down. Fair analysis. Very Fair,Roland Peralta: (01:00:26) very fair. So yeah, so that this is this part of our challenge as a company is, is communicating to men the importance of taking the path of prevention and getting off the path of denial. Right. And that’s fundamentally the problem with men. I have a 23 year old boy who went to school in Sweden. I get to see him once a year and a year three he comes back and he’s got a little, a little spot brewing on the back of his head. I thought, Oh, my child cannot lose his hair. So, and he’s these stubborn kid, he doesn’t take pills. And so, I said, all right, how do, how do I ah, compel him into compliance and, and say, yes, Papa, I will take these pills because it doesn’t make sense to be proactive. And preventative because I don’t want to lose my hair by the time I’m 30 so he has been on it for about a year. The spot filled in and for 23 year old, that’s a home run. He basically proof is in the pudding. It’s like you, you cannot, there’s no denying that it improved your hair growth.Dr. Anil Shah: (01:01:35) And I almost think the analogy here for hair is almost like, it’s like dental disease. If you don’t brush your teeth every day, you’re going to lose your teeth. It’s just that’s inevitable. If you don’t take your hair pills, you’re going to lose your hair. It’s like one of the things you’re, you’re preserving what’s there. And sometimes that aspect of it. by the way, I’m just, I’m so much, your son’s a great example because if your son was to take Propecia, would it have worked? I have no idea. Would it have affected him on some level? Probably. Would it affected his offspring, Aka your grandkids? Who knows? Who would wants to take that chance? I’m taking something like Nutrafol if anything is going to make them healthier, a better version of himself. Let more resistant to infections, you know, more vibrancy or the nitric oxide thing. You might want to have a serious conversation with him.Roland Peralta: (01:02:24) But I left that part out. I don’t know why I left that part out. I’ll send them a note later today. That’s very funny. He’ll appreciate that.Dr. Anil Shah: (01:02:37) So huge, huge fan. so, so a love this. So three tips. I’m a facial plastic surgeon, loves hair. I’ve had my hair story. My wife’s not here to share her hair story. love Nutrafol love how it’s a holistic approach to my patients. Love how it helps them see that those benefits in patients, you know, every day. See it on a microscopic level with try cross scopy, see it in their care, see it in their before and after results. three tips. Patients, someone comes to you says, I want three tips to be my best. Just random tips can be anything we can look at that note. So,Roland Peralta: (01:03:11) so, so the tips could be lifestyle related, right? Yeah. Anything, right. So I, I’ve recently started intermittent fasting. And what are your hours? I am doing, I do 16 eight and then I do 24 right? So I’m basically, I have lunch from, from two. I eat from two to six. Typically my last meal is at six and then I have lunch at at two o’clock. But I’m, and I’m doing it in the name of, it’s part of the biohacking mindset, right? So it turns out that intermittent fasting, but the longer you fast, the better the outcome. I’m triggering autophagy. So the, the human body has these little light. Lysosomes are human vacuum cleaners on a cellular level that are designed to basically start eating up non-essential parts in the human body that interfere with, with healthy cellular function. Well, it turns out that you can make a direct correlation to hair follicle cycling and, and, and cells that are involved in, in the hair growth cycle, triggering autophagy where the body starts eating itself after a 24 to 48 hour fasting, they say they go in there and they clean up all of the oxidative stress and not essential parts, convert them into amino acids and they turned them into two functional function, functionable a, foods, right for the human body.Roland Peralta: (01:04:36) So I’m doing that intermittent fasting in the spirit of improving health and as consequently my hair, hair, health.Dr. Anil Shah: (01:04:43) Question on that. That was one of my questions is, so, the hardest part for me would within investing is I do the 16, eight. so usually I skip breakfast so to speak, but I like taking my nutrifox I have to take it with fat. and in the morning, no, take it with lunch, lunch. yeah, that’s probably a better idea. I, it’sRoland Peralta: (01:05:03) because if you’re not having breakfast, if not having breakfast, you’d rather say, take your four pills a day with, with lunch or dinner, whichever is your fattiest meal. But if you want to stick, you want to create a routine and, and, and drive people in. You keep a bottle on your desk at the office because you’re probably eating at your desk three days a week, or five days a week or because you’re probably seeing some patients, when you’re not eating at your desk, or keep one in your kitchen.Speaker 3: (01:05:32) I still have a desk, but if you don’t really like five, I’m like pepe death. That’s good. Felt like, I dunno, it’s like eighties. Yeah. Cause you’re gonna level. It’s kind, Kinda like, you know, talk, show host. It’s like, you know, you put your seat up high, then you have your feet low and then, yeah, I just don’t like a desk so I just have a cop. So lucky you lucky you. I’ll see ya. So I would definitely, but, but do, do, do your best to take it with a fatty meal with, with one of your meals that has the most fat. Yup. Okay. Yeah.Roland Peralta: (01:05:59) The next, the next, tip I would say is really embrace the idea of how important your liver, is to your overall health and consequently to your hair. Wellness and liver is really important. So there have been studies that show that, people who take, when you compare people who, took a break from all alcohol for 30 days, some of the liver enzymes, liver function improved dramatically versus the people who continued to drink. So, because we know how important liver is to hair, health, hair, wellness, hair cycling, it makes so much sense to really pamper the liver. include products like the neutral liver cleanse. If you have your own favorite liver cleanse product, by all means, use it, but use it, do anything you can to support, the liver. It’s, it’s, it is the filter for the human body. The cleaner and the more optimize it is, the better we will be functioning as humans.Roland Peralta: (01:07:08) very, very important. And then the other is managing stress, managing stress through perhaps that’s that’s, another best tip of the day is really how do you manage stress? Well, certainly yoga and meditation, a mindfulness practice all help. But of course we live in a society where we don’t all have the, the, the, the, the discipline to carve out time to go to the gym, to do yoga class to meditate. So stress adaptogens are a wonderful way of supporting supporting stress management. We introduced, as you know, Nutrafol does have stress adaptogens in it, but we introduced a booster that we’re, that’s an additional stress adaptive for people who have higher stress levels and we’re using Reishi mushrooms, some additional Ashford Ganda. these are all wonderful ingredients that are, have evidence in the literature of lowering stress levels. So those are my two. I absolutely, I would highly recommend having a stress adapted in, in your routine, a liver cleanse in your routine. And, and something as simple asSpeaker 3: (01:08:16) intermittent fasting, all would contribute to her overall good hair, well and wellness. Amazing. So, so much amazing things. I probably could talk for another hour, but you must do it again. I think the coolest thing,Dr. Anil Shah: (01:08:28) my take on point is, you know, sometimes it’s nice to do, like you’ve type people like get lost in this world of hair and they’re doing all this research and what’s the best, what not the best. And I think it’s nice to have a company that’s sort of done a best of and thought, you know, very thoughtfully in so many different levels of what’s the best way to get so many quality ingredients. Let’s do the best way of thinking about it. Even the way we process ourselves Komeito the way we get our content. I mean, there’s so many different things that are thought in this, hey, let’s get some science behind this because this is a really important thing about it. And this is not just about your hair because your hair, your hair and your skin, but your hair, it’s a sign of your health, your overall health, this, your attractiveness. And that’s what makes us human to be the best version of ourselves. So I think it’s great. For what you’ve done with Nutrafol. Thank you so much for me as you know, as a user of Nutrafol and for all my patients.Speaker 3: (01:09:20) Thank you. Thank you. I appreciate that very much. Thanks so much.Dr. Anil Shah: (01:09:23) Being on here and, educating me on what I’m doing wrong with my knee.Speaker 3: (01:09:27) Oh, now I’m going to know that I’ve had a wonderful time, Dr Shah. Thank you for inviting me. Thank you. Thank you so much. We’ll appreciate it. Thank you. Bye. Bye. Bye.